Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury

Hui He, Xiufang Li, and Yuling He

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354685/


Given that the therapeutic effect of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) has been debated for a long time, it is necessary to clarify the mechanism underlying the effect of HBO on acute TBI.


This study investigated the effect of HBO therapy on neuronal apoptosis induced by acute TBI using the mouse model of TBI. The number of apoptotic cells and expression of apoptosis-associated factors (including caspase 3, pAkt/Akt, pGSK3β/GSK3β, and β-catenin) in pericontusional cortices of mice exposed to sham, TBI, and TBI + HBO treatment were measured and analyzed using TUNEL assay, quantitative reverse-transcription PCR, and Western blot.


Results showed that acute TBI increased the number of apoptotic neurons and mRNA expression and activated caspase 3 protein. With regard to proteins, acute TBI also resulted in decreased levels of pAkt/Akt, pGSK3β/GSK3β, and β-catenin, which facilitates neuronal apoptosis. This study shows that HBO therapy reversed these changes of pAkt/Akt, pGSK3β/ GSK3β, and β-catenin induced by acute TBI and attenuated the apoptotic process in the pericontusional cortex.


This study demonstrates the beneficial effect of HBO therapy on neuronal apoptosis caused by acute TBI. Furthermore, the mechanism underlying the therapeutic effect of HBO on acute TBI partly involves the Akt/GSK3β/β-catenin pathway.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354685/

By continuing to browse you are agreeing to our use of cookies as explained in our Cookie Policy.

  • Facebook
  • Twitter
  • Instagram
  • LinkedIn Social Icon

Hyperbaric Medicine International (HMI)  |  PO Box 450 Westtown, PA 19395-0450  |  484-639-9006

© Copyright 2019-2020 Hyperbaric Medicine International, all rights reserved. HMI is a 501(c)(4) Information provided by Hyperbaric Medicine International does not constitute medical diagnosis or recommendations, and is intended for informational purposes only.